反应详情

1.00 g (5.02 mmol) of 6-bromo-9H-purine (purchased from Aldrich; cat. no. 104981) was suspended in 10 mL of DMF and potassium carbonate (2.08 g, 15.05 mmol) was added. The mixture was stirred at room temperature for 20 minutes and then 1-(chloromethyl)-4-methoxybenzene (1.40 mL, 10.06 mmol) were added. The reaction mixture was stirred at 45° C. overnight. Then the mixture was evaporated to dryness and the residue was partitioned between water and dichloromethane. The organic layer was washed with water and brine, dried over magnesium sulphate, filtered and the solvent was removed in vacuum. The product was purified by flash chromatography (0% to 50% hexane/AcOEt) to yield 447 mg (28%) of the title compound.

1. stirringThe reaction mixture was stirred at 45° C. overnight
2. customThen the mixture was evaporated to dryness
3. customthe residue was partitioned between water and dichloromethane
4. washThe organic layer was washed with water and brine
5. dry with materialdried over magnesium sulphate
6. filtrationfiltered
7. customthe solvent was removed in vacuum
8. customThe product was purified by flash chromatography (0% to 50% hexane/AcOEt)