Hydrochloric Acid → HCID 11424340, compound

HRID 526038Notes

Reaction equation

HRID 526038 reaction equation
[CH2:1]([O:3][C:4](=[CH:10][C:11]1[CH:16]=[CH:15][C:14]([N+:17]([O-])=O)=[CH:13][CH:12]=1)[C:5]([O:7]CC)=[O:6])[CH3:2].CN(C=O)C.[OH-].[Na+].Cl>O>[CH2:1]([O:3][CH:4]([CH2:10][C:11]1[CH:12]=[CH:13][C:14]([NH2:17])=[CH:15][CH:16]=1)[C:5]([OH:7])=[O:6])[CH3:2]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 14798Sodium HydroxideHCID 66905768Ethyl 2-ethoxy-3-(4-nitrophenyl)prop-2-enoate

Product 1

HCID 11424340HCID 11424340, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Ethyl 2-ethoxy-3-(4-nitrophenyl)acrylate containing 3.6 wt % DMF (26.07 g corrected, 98.3 mmol) was dissolved in IMS (500 ml) and a solution of NaOH (1.44 g, 36.1 mmol) in water (260 ml) was added. The resulting mixture was stirred at ambient temperature for 18 hr then acidified with 1M HCl (120 ml) and the resulting solid collected by filtration, washed with water (2×100 ml) and suction dried on the filter for 30 mins, followed by vacuum oven drying at 18° C. for 18 hr.

Workup

  1. filtrationthe resulting solid collected by filtration
  2. washwashed with water (2×100 ml) and suction
  3. customdried on the
  4. filtrationfilter for 30 mins
  5. customdrying at 18° C. for 18 hr

Sources & evidence

ORD record
ord-f8b01ec608244fafaddd90f5ef9845b2
Source dataset
uspto-grants-2016_05
Patent number
US09345680B2

Reaction notes

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