Hydrochloric Acid → HCID 178478720, compound

HRID 526163Notes

Reaction equation

HRID 526163 reaction equation
[N:1]1([CH2:6][C@H:7]2[CH2:12][CH2:11][C@H:10]([NH:13]C(=O)OC(C)(C)C)[CH2:9][CH2:8]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:21].O>C1COCC1>[ClH:21].[ClH:21].[N:1]1([CH2:6][C@H:7]2[CH2:8][CH2:9][C@H:10]([NH2:13])[CH2:11][CH2:12]2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 178453932HCID 178453932, compound

Product 1

HCID 178478720HCID 178478720, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
65 °C

Procedure

To a solution of tert-butyl (trans-4-(pyrrolidin-1-ylmethyl)cyclohexyl)carbamate (1.3 g, 4.5 mmol) in THF (15 mL) was added aqueous 6 N HCl (6 mL) and water (6 mL) and the reaction mixture was stirred with heat at 65° C. for 3 h. The reaction mixture was cooled to room temperature and concentrated to afford the desired product (1.2 g, >99%) as an off-white solid. ESI MS m/z 183 [C11H22FN2+H]+

Workup

  1. temperatureThe reaction mixture was cooled to room temperature
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-0c3c8a92f77048259a4db9596e2834a9
Source dataset
uspto-grants-2016_05
Patent number
US09345709B2

Reaction notes

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