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HRID52658

反应详情

EQUATION

反应方程式

HRID 52658 的结构方程式

REACTANTS

反应物

4
结构：O
HCID962

Water

H2O

结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：Cc1c(B(O)O)ccc2nc(N)nc(N)c12
HCID53792440

未命名化合物

结构：CC1(C)Oc2cccc(Br)c2C1=O
HCID54377906

4-Bromo-2,3-dihydro-2,2-dimethyl-3-benzofuranone

C10H9BrO2

PRODUCTS

生成物

1
结构：Cc1c(-c2cccc3c2C(=O)C(C)(C)O3)ccc2nc(N)nc(N)c12
HCID86749623

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：c1ccc([P](c2ccccc2)(c2ccccc2)[Pd]([P](c2ccccc2)(c2ccccc2)c2ccccc2)([P](c2ccccc2)(c2ccccc2)c2ccccc2)[P](c2ccccc2)(c2ccccc2)c2ccccc2)cc1
催化剂HCID178418397

未命名化合物

结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

CONDITIONS

反应条件

温度
90 °C

PROCEDURE

实验过程

A solution of 2.1 grams (0.010 mole) of (2,4-diamino-5-methylquinazolin-6-yl)boronic acid in 25 mL of N,N-dimethylformamide is stirred, and 2.1 grams (0.009 mole) of 4-bromo-2,3-dihydro-2,2-dimethyl-3-benzofuranone (prepared in Step C of this Example), 2.8 grams (0.020 mole) of potassium carbonate, and 0.31 gram (catalyst-3 mole %) of tetrakis(triphenylphosphine)palladium(0) are added. The reaction mixture is then warmed to 90° C., where it is stirred for about 16 hours. After this time the reaction mixture is poured into water. The resultant precipitate is collected by filtration and dried, yielding 2,4-diamino-5-methyl-6-(2,3-dihydro-2,2-dimethyl-3-benzofuranon-4-yl)quinazoline.

WORKUP

后处理

  1. additionare added
  2. filtrationThe resultant precipitate is collected by filtration
  3. customdried