反应详情

温度

22.5 °C

To a solution of eslicarbazepine (30 gm), triethylamine (19.7 gm), dimethylaminopyridine (0.15 gm), and dichloromethane (150 mL), acetic anhydride (14.5 mL in 14.5 mL dichloromethane) was added and solution was stirred at about 20-25° C. for about 3 hrs. The resulting solution was cooled to about 10-15° C. To the resulting solution water (90 mL) was added followed by addition of HCl till pH of the resulting solution was 1-2. Organic layer was separated and washed with water. Water was added to organic layer followed by cooling to about 10-15° C. The pH of the resulting solution was adjusted to 9-10 by adding NaOH (10% w/v) solution. Organic layer was separated and solvent was distilled out completely to obtain the title compound.

1. temperatureThe resulting solution was cooled to about 10-15° C
2. customOrganic layer was separated
3. washwashed with water
4. additionWater was added to organic layer
5. temperatureby cooling to about 10-15° C
6. additionby adding NaOH (10% w/v) solution
7. customOrganic layer was separated
8. distillationsolvent was distilled out completely