Dichloromethane → HCID 86706428, compound

HRID 526681Notes

Reaction equation

HRID 526681 reaction equation
[CH2:1]([O:5][C:6]([NH:8][CH:9]([CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:10](O)=[O:11])=[O:7])[CH:2]([CH3:4])[CH3:3].[Cl:20]CCl.S(Cl)(Cl)=O>CN(C)C=O>[CH2:1]([O:5][C:6](=[O:7])[NH:8][CH:9]([C:10]([Cl:20])=[O:11])[CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH:2]([CH3:4])[CH3:3]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 24386Thionyl ChlorideHCID 15076055HCID 15076055, compound

Product 1

HCID 86706428HCID 86706428, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A solution of 2-isobutoxycarbonylamino-3-phenyl-propionic acid (5 gm), dichloromethane (25 mL) and dimethylformamide (0.5 mL) was cooled to 0-5° C. To the resulting solution, thionyl chloride (1.5 mL) was added at same temperature. The solvent was distilled out completely to obtain the title compound.

Workup

  1. distillationThe solvent was distilled out completely

Sources & evidence

ORD record
ord-9590761eab8c45b3bcd017e3d9d663fb
Source dataset
uspto-grants-2016_05
Patent number
US09346760B2

Reaction notes

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