反应详情

温度

90 °C

To a solution of N-benzyl-N-(3-hydroxy-4,4-dimethoxybutyl)-2-nitrobenzenesulfonamide (0.212 g, 0.5 mmol) in 1-Propanol (1.5 ml) was added 37% hydrochloric acid (0.104 ml, 1.250 mmol) and the mixture was stirred at 90° C. in a weaton vial. Cooled, evaporated to dryness under vacuum, applied on a column in petroleum ether-ethyl acetate mixture 1:1, eluted with the same system. Fractions collected to give N-benzyl-N-(4-hydroxy-3-oxobutyl)-2-nitrobenzenesulfonamide (0.085 g, 0.225 mmol, 44.9% yield), yellowish oil.

1. temperatureCooled
2. customevaporated to dryness under vacuum
3. washeluted with the same system
4. customFractions collected