反应详情

To a solution of tert-butyl 2-[(3S)-3-[[2-[5-chloro-1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridin-3-yl]-5-fluoro-pyrimidin-4-yl]amino]-1-piperidyl]acetate, 2a, (0.27 g, 0.44 mmol) in THF was added 1N LiOH solution. The reaction mixture was heated in microwave at 120 degrees for 10 minutes. The reaction mixture diluted with brine, extracted with EtOAc, then with 20% isopropanol/CH2Cl2. The combined organic phases were dried (MgSO4), filtered and concentrated in vacuo. The resulting product, 2b, was used without further purification.

1. temperatureThe reaction mixture was heated in microwave at 120 degrees for 10 minutes
2. extractionextracted with EtOAc
3. dry with materialThe combined organic phases were dried (MgSO4)
4. filtrationfiltered
5. concentrationconcentrated in vacuo
6. customThe resulting product, 2b, was used without further purification