反应详情

2-hydroxy-2-(4-isopropyl-2-methoxyphenyl)-4-nitro-2H-inden-1,3-dione (52 mg, 1.4 mmol) was completely dissolved in anhydrous ethanol (10 ml). This solution was added with iron (0.59 g, 10.6 mmol), conc. HCl (0.01 ml) and water (1 ml). The reaction mixture was heated for 3 hrs under reflux. After filtration at high temperature to remove iron, the filtrate was concentrated in a vacuum and purified using column chromatography (ethylacetate:hexane=1:2) to afford the title compound (0.32 g, 68%).

1. temperatureThe reaction mixture was heated for 3 hrs
2. temperatureunder reflux
3. filtrationAfter filtration at high temperature
4. customto remove iron
5. concentrationthe filtrate was concentrated in a vacuum
6. custompurified