HCID 71295412, compound → 2,4-Dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-2-(2-methylpropyl)-3H-1,2,4-triazol-3-one

HRID 527179Notes

Reaction equation

HRID 527179 reaction equation
[CH2:1]([N:5]1[C:9](=[O:10])[N:8]([C:11]2[CH:16]=[CH:15][C:14]([N:17]3[CH2:22][CH2:21][N:20]([C:23]4[CH:28]=[CH:27][C:26]([O:29]C)=[CH:25][CH:24]=4)[CH2:19][CH2:18]3)=[CH:13][CH:12]=2)[CH:7]=[N:6]1)[CH:2]([CH3:4])[CH3:3]>Br>[OH:29][C:26]1[CH:27]=[CH:28][C:23]([N:20]2[CH2:19][CH2:18][N:17]([C:14]3[CH:13]=[CH:12][C:11]([N:8]4[C:9](=[O:10])[N:5]([CH2:1][CH:2]([CH3:4])[CH3:3])[N:6]=[CH:7]4)=[CH:16][CH:15]=3)[CH2:22][CH2:21]2)=[CH:24][CH:25]=1

Participants

3

Reactant 1

HCID 71295412HCID 71295412, compound

Product 1

HCID 151255642,4-Dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-2-(2-methylpropyl)-3H-1,2,4-triazol-3-oneYield 91%

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Procedure

This compound was synthesized as a white amorphous solid from 4f (64.0 mg, 0.152 mmol) in 48% aqueous HBr (1.5 mL) in 91% yield by following general procedure 1.4: MALDI-MS: 394.2 (M+H+), 416.2 (M+Na+).

Sources & evidence

ORD record
ord-b14debb5235d4567b9fcf0e25156f8d6
Source dataset
uspto-grants-2016_05
Patent number
US09346791B2

Reaction notes

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