反应详情

温度

110 °C

In a 0.5-2.0 ml micro-wave vial 3-ethyl-1,3-dihydro-2-benzofuran-4-ol (Intermediate 106, 49.7 mg) was dissolved in N,N-dimethylformamide (1.5 ml) to give a pale yellow solution. 2-chloro-5-nitropyridine (48.0 mg, 0.303 mmol) and potassium carbonate (125 mg, 0.908 mmol) were added. The reaction vessel was sealed and heated in micro-wave Biotage Initiator at 110° C. for 1 hour. After cooling, the reaction completed. The reaction mixture was then quenched with 5 ml of water and diluted with 25 ml of Et2O. The aqueous phase was extracted with 3×10 ml of Et2O. The collected organic phases were passed through a phase separator cartridge and evaporated under vacuum to give the title compound as a pale yellow oil (97.6 mg).

1. customto give a pale yellow solution
2. customThe reaction vessel was sealed
3. temperatureAfter cooling
4. customThe reaction mixture was then quenched with 5 ml of water
5. additiondiluted with 25 ml of Et2O
6. extractionThe aqueous phase was extracted with 3×10 ml of Et2O
7. customevaporated under vacuum