m-Chloroperbenzoic acid → 2-Methyl-propane-2-sulfonic acid (2-bromo-ethyl)-amide

HRID 527852Notes

Reaction equation

HRID 527852 reaction equation
[Br:1][CH2:2][CH2:3][NH:4][S:5]([C:7]([CH3:10])([CH3:9])[CH3:8])=[O:6].C1C=C(Cl)C=C(C(OO)=[O:19])C=1>>[Br:1][CH2:2][CH2:3][NH:4][S:5]([C:7]([CH3:10])([CH3:9])[CH3:8])(=[O:19])=[O:6]

Participants

3

Reactant 2

HCID 70297m-Chloroperbenzoic acidHCID 867137312-Methyl-propane-2-sulfinic acid (2-bromo-ethyl)-amide

Product 1

HCID 636888052-Methyl-propane-2-sulfonic acid (2-bromo-ethyl)-amideYield 46.8%

Conditions

Temperature
25 °C

Procedure

To a solution of 2-methyl-propane-2-sulfinic acid (2-bromo-ethyl)-amide (0.8 g, 3.5 mmol) was added mCPBA (77%, 0.95 g, 4.2 mmol) and stirred at a temperature of about 25° C. for 2 hrs. The reaction mixture was condensed and purified to provide 2-methyl-propane-2-sulfonic acid (2-bromo-ethyl)-amide as a white solid (0.4 g, 46% yield).

Workup

  1. customcondensed
  2. custompurified

Sources & evidence

ORD record
ord-9955dfe097094ee2be6631161f9d01e9
Source dataset
uspto-grants-2016_05
Patent number
US09346808B2

Reaction notes

Loading…