Hydrochloric Acid → HCID 86711709, compound

HRID 528019Notes

Reaction equation

HRID 528019 reaction equation
C[O:2][C:3]1[C:12](=O)[N:11]([CH3:14])[C:10]2[N:9]=[CH:8][N:7]=[C:6]([N:15]3[CH2:31][CH2:30][C:18]4([N:22]([C:23]5[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=5)[CH2:21][NH:20][C:19]4=[O:29])[CH2:17][CH2:16]3)[C:5]=2[N:4]=1.[OH2:32].[OH-].[Li+].Cl>O>[CH3:14][N:11]1[C:12]([C:3]([OH:32])=[O:2])=[N:4][C:5]2[C:10]1=[N:9][CH:8]=[N:7][C:6]=2[N:15]1[CH2:31][CH2:30][C:18]2([N:22]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH2:21][NH:20][C:19]2=[O:29])[CH2:17][CH2:16]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 168937Lithium hydroxide, monohydrateHCID 66800080HCID 66800080, compound

Product 1

HCID 86711709HCID 86711709, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
60 °C

Procedure

6-Methoxy-8-methyl-4-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]dec-8-yl)pteridin-7(8H)-one (1 g, 2.37 mmol) was treated with lithium hydroxide monohydrate (0.281 g, 4.74 mmol) tetrahydrofuran (2.5 mL) and water (2.5 mL). This mixture was stirred at 60° C. for 48 hours. The reaction mixture was cool to room temperature acidified to pH 4 with 1 M hydrochloric acid (8 mL) and evaporated under reduced pressure. The resulting crude material was then used in the next step without any further purification. MS (EI) for C20H21N7O3: 408 (MH+), 364 (MH+−44 (—CO2)).

Workup

  1. temperatureThe reaction mixture was cool to room temperature
  2. customevaporated under reduced pressure
  3. customThe resulting crude material was then used in the next step without any further purification

Sources & evidence

ORD record
ord-5b8a3e202e7a4c3d8a6cbc5cac6ae946
Source dataset
uspto-grants-2016_05
Patent number
US09346807B2

Reaction notes

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