反应详情

To 65 mg (0.65 mmol) of the compound from Example 336D in methylene chloride was added 0.079 mL of 4-methylmorpholine and 144 mg (0.715 mmol) of p-nitrophenoxycarbonylchloride. The mixture was stirred for 2 hours, diluted with solvent, washed with saturated brine, and the solvent removed. The residue was chromatographed on a silica gel column, eluting with 20% and 30% ethyl acetate in hexane. The solvent was removed and the product dried to afford 0.115 g of the title product.

1. additiondiluted with solvent
2. washwashed with saturated brine
3. customthe solvent removed
4. customThe residue was chromatographed on a silica gel column
5. washeluting with 20% and 30% ethyl acetate in hexane
6. customThe solvent was removed
7. customthe product dried