Trifluoroacetic acid → 3-Benzothiazol-2-yl-azetidine trifluoroacetate

HRID 528739Notes

Reaction equation

HRID 528739 reaction equation
C(OC([N:8]1[CH2:11][CH:10]([C:12]2[S:13][C:14]3[CH:20]=[CH:19][CH:18]=[CH:17][C:15]=3[N:16]=2)[CH2:9]1)=O)(C)(C)C.[C:21]([OH:27])([C:23]([F:26])([F:25])[F:24])=[O:22]>C(Cl)Cl>[F:24][C:23]([F:26])([F:25])[C:21]([OH:27])=[O:22].[S:13]1[C:14]2[CH:20]=[CH:19][CH:18]=[CH:17][C:15]=2[N:16]=[C:12]1[CH:10]1[CH2:9][NH:8][CH2:11]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 442398183-Benzothiazol-2-yl-azetidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 674587613-Benzothiazol-2-yl-azetidine trifluoroacetate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To 48 mg (166 μmol) 3-benzothiazol-2-yl-azetidine-1-carboxylic acid tert-butyl ester was added 5 mL DCM and 5 mL TFA. The resulting mixture was stirred at room temperature for 30 minutes. The solvent was evaporated to give the product as the TFA salt which was used in the next step without further purification.

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-f3496f97b59944cf94bf5c815d221f4b
Source dataset
uspto-grants-2016_05
Patent number
US09346816B2

Reaction notes

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