Triethylamine → 4,4,4-Trifluoro-N-(4,4,4-trifluorobutyl)butan-1-amine

HRID 528890Notes

Reaction equation

HRID 528890 reaction equation
CC[N:3]([CH2:6][CH3:7])[CH2:4][CH3:5].[F:8][C:9]([F:15])([F:14])[CH2:10]CC=O>>[F:15][C:9]([F:8])([F:14])[CH2:10][CH2:7][CH2:6][NH:3][CH2:4][CH2:5][CH2:10][C:9]([F:15])([F:14])[F:8]

Participants

3

Reactant 2

HCID 8471TriethylamineHCID 27770834,4,4-Trifluorobutanal

Product 1

HCID 1874074,4,4-Trifluoro-N-(4,4,4-trifluorobutyl)butan-1-amine

Procedure

Following a procedure analogous to that for the synthesis of Example 106, 4,4,4-trifluorobutan-1-amine, HCl (598 mg, 4.00 mmol), Et3N (550 μL, 4.00 mmol) and 4,4,4-trifluorobutanal (504 mg, 4.00 mmol) provided a colorless oil which was used directly in the preparation of Example 129. MS(ESI+) m/z 192.1 (M+H)+.

Workup

  1. customprovided a colorless oil which
  2. customwas used directly in the preparation of Example 129

Sources & evidence

ORD record
ord-5da0de8d1d4340aca2519c4beee7054b
Source dataset
uspto-grants-2016_05
Patent number
US09346795B2

Reaction notes

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