Hydrochloric Acid → HCID 10764699, compound

HRID 52891Notes

Reaction equation

HRID 52891 reaction equation
Cl.[C:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]1[CH:16]=[CH:15][C:14]([CH2:17][N:18]2[C:22]([C:23]([O:25]CC)=[O:24])=[C:21]([C:28]([OH:31])([CH3:30])[CH3:29])[N:20]=[C:19]2[CH2:32][CH2:33][CH3:34])=[CH:13][CH:12]=1)([OH:4])=[O:3].O.[OH-].[Li+].Cl>O>[C:2]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]1[CH:12]=[CH:13][C:14]([CH2:17][N:18]2[C:22]([C:23]([OH:25])=[O:24])=[C:21]([C:28]([OH:31])([CH3:29])[CH3:30])[N:20]=[C:19]2[CH2:32][CH2:33][CH3:34])=[CH:15][CH:16]=1)([OH:4])=[O:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 168937Lithium hydroxide, monohydrateHCID 19036164HCID 19036164, compound

Product 1

HCID 10764699HCID 10764699, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 0.20 g of ethyl 1-[(2'-carboxybiphenyl-4-yl)methyl]-4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate hydrochloride (prepared as described in Example 16) in an aqueous solution of 84 mg of lithium hydroxide monohydrate in 5 ml of water was stirred at room temperature for 6 hours. At the end of this time, 2 ml of 1N aqueous hydrochloric acid were added dropwise to the reaction mixture, and the resulting precipitate was collected by filtration, to give 0.17 g of the title compound, melting at 176°-179° C. (with decomposition).

Workup

  1. filtrationthe resulting precipitate was collected by filtration

Sources & evidence

ORD record
ord-da2f274691dd4ed6b2ddeec5d883684b
Source dataset
uspto-grants-1997_04
Patent number
US05616599

Reaction notes

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