2-Fluoroethyl bromide → HCID 79035246, compound

HRID 529048Notes

Reaction equation

HRID 529048 reaction equation
[H-].[Na+].[Br:3][C:4]1[CH:5]=[N:6][NH:7][CH:8]=1.Br[CH2:10][CH2:11][F:12]>CN(C=O)C>[Br:3][C:4]1[CH:5]=[N:6][N:7]([CH2:10][CH2:11][F:12])[CH:8]=1

Participants

5

Reactant 3

HCID 129822-Fluoroethyl bromideHCID 163754-BromopyrazoleHCID 24758Sodium hydride

Product 1

HCID 79035246HCID 79035246, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Procedure

Sodium hydride (24.22 mg, 0.606 mmol, 60% suspension in mineral oil) was added to a solution of 4-bromo-1H-pyrazole (89 mg, 0.606 mmol) in DMF (3028 μl) at RT. After 15 min, 1-bromo-2-fluoroethane (100 mg, 0.787 mmol) was added to the mixture. After 30 min, the mixture was diluted with DMF and purified by HPLC, followed by neutralization (K2CO3), to afford the title compound as a colorless oil.

Workup

  1. waitAfter 30 min
  2. custompurified by HPLC

Sources & evidence

ORD record
ord-8eeaf2ac8c8b4cb883715a2d013ed4af
Source dataset
uspto-grants-2016_05
Patent number
US09346829B2

Reaction notes

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