Cyclopentanone → HCID 69811682, compound

HRID 529126Notes

Reaction equation

HRID 529126 reaction equation
[C:1]1(=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:7][CH2:8][C:9]1[C:14]([Cl:15])=[CH:13][CH:12]=[C:11]2[N:16]([C:31]3[C:32]4[C@H:39]([CH3:40])[CH2:38][CH2:37][C:33]=4[N:34]=[CH:35][N:36]=3)[CH2:17][C:18]3([CH2:23][CH2:22][N:21]([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH2:20][CH2:19]3)[C:10]=12.[BH-](OC(C)=O)(OC(C)=O)OC(C)=O.[Na+]>ClCCCl.C(Cl)Cl>[Cl:15][C:14]1[C:9]([CH2:8][NH:7][CH:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)=[C:10]2[C:18]3([CH2:23][CH2:22][N:21]([C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH2:20][CH2:19]3)[CH2:17][N:16]([C:31]3[C:32]4[C@H:39]([CH3:40])[CH2:38][CH2:37][C:33]=4[N:34]=[CH:35][N:36]=3)[C:11]2=[CH:12][CH:13]=1

Participants

6

Reactant 3

HCID 8452CyclopentanoneHCID 5049666Sodium triacetoxyborohydrideHCID 68758918HCID 68758918, compound

Product 1

HCID 69811682HCID 69811682, compoundYield 57.4%

Reagents, catalysts & solvents 2

HCID 111,2-DichloroethaneSolventHCID 6344DichloromethaneSolvent

Procedure

Cyclopentanone (17.4 mg, 0.207 mmol) was added to a solution of (R)-tert-butyl 4-(aminomethyl)-5-chloro-1-(5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)spiro[indoline-3,4′-piperidine]-1′-carboxylate (20 mg, 0.041 mmol) in DCE (2 mL). The reaction was allowed to stir at room temperature for 15 minutes, at which point Na(OAc)3BH (22 mg, 0.103 mmol) was added. The reaction was allowed to stir overnight. The reaction mixture was diluted with DCM, washed with saturated aqueous NaHCO3 solution and brine, dried with MgSO4 and concentrated. The residue was purified by column chromatography (15:1, DCM:MeOH) to give (R)-tert-butyl 5-chloro-4-((cyclopentylamino)methyl)-1-(5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)spiro[indoline-3,4′-piperidine]-1′-carboxylate (13 mg, 54%) as an oil. LCMS (APCI+) m/z 552/554 [M+H]+; Rt=4.79 min. This material was taken up into DCM (2 mL), and 2N HCl in ether was added (1 mL). The reaction was allowed to stir for 1 hour, at which point it was concentrated to give (R)—N-((5-chloro-1-(5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)spiro[indoline-3,4′-piperidine]-4-yl)methyl)propan-2-amine trihydrochloride salt (12 mg, 52%) as a solid. 1H NMR (D2O, 400 MHz) δ 8.53 (s, 1H), 7.74 (d, J=8.8 Hz, 1H), 7.40 (d, J=8.8 Hz, 1H), 4.55-4.39 (m, 3H), 4.17-4.15 (m, 1H), 3.84-3.38 (m, 7H), 3.17-2.97 (m, 4H), 2.44-1.67 (m, 14H). LCMS (APCI+) m/z 452/454 [M+H]+; Rt=2.52 min.

Workup

  1. additionwas added
  2. washwashed with saturated aqueous NaHCO3 solution and brine
  3. dry with materialdried with MgSO4
  4. concentrationconcentrated
  5. customThe residue was purified by column chromatography (15:1, DCM:MeOH)

Sources & evidence

ORD record
ord-16f8c683814747d5bc0e0392610c9876
Source dataset
uspto-grants-2016_05
Patent number
US09346805B2

Reaction notes

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