Trifluoroacetic acid → 7-bromo-4-fluoro-2-methoxy-9H-xanthen-9-one

HRID 529397Notes

Reaction equation

HRID 529397 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:11][C:12]2[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][C:13]=2[F:20])=[C:6]([CH:10]=1)[C:7]([OH:9])=O.C(O)(C(F)(F)F)=O.C(OC(C(F)(F)F)=O)(C(F)(F)F)=O.B(F)(F)F.CCOCC>O>[Br:1][C:2]1[CH:10]=[C:6]2[C:5]([O:11][C:12]3[C:13]([F:20])=[CH:14][C:15]([O:18][CH3:19])=[CH:16][C:17]=3[C:7]2=[O:9])=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 6422Trifluoroacetic acidHCID 8000Boron trifluoride etherateHCID 9845Trifluoroacetic anhydrideHCID 574756385-Bromo-2-(2-fluoro-4-methoxyphenoxy)benzoic acid

Product 1

HCID 574756397-bromo-4-fluoro-2-methoxy-9H-xanthen-9-oneYield 58.8%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
0 °C

Procedure

A dry 100 L glass jacketed reactor equipped with an addition funnel, reflux condenser and temperature probe was charged with 5-bromo-2-(2-fluoro-4-methoxyphenoxy)benzoic acid (2340 g, 6.9 mol). TFA (11.7 L) was carefully added to the solution followed by TFAA (1144 mL). Boron trifluoride diethyl etherate (85 mL, 0.68 mol) was then carefully added to the reaction mixture. The mixture was stirred for 4 hours at which point the reaction was transferred to another 100 L glass reactor containing 35.1 L of water cooled to 0° C. The resulting slurry was allowed to warm to RT and stir for 1 hour. The solids were filtered and washed with water (4.7 L) and 3 N NaOH (2×3.5 L) and water (7 L). The solids were transferred into a 22 L reactor and acetone (4.7 L) was added. The solids were slurried for 1.5 hour and the filtered, washing well with acetone (4.7 L). An additional slurry with acetone (6.4 L@ 45° C.) provided 1310 g of 7-bromo-4-fluoro-2-methoxy-9H-xanthen-9-one as an off white solid.

Workup

  1. customequipped with an addition funnel
  2. temperaturereflux condenser
  3. customwas transferred to another 100 L glass reactor
  4. temperatureto warm to RT
  5. stirringstir for 1 hour
  6. filtrationThe solids were filtered
  7. washwashed with water (4.7 L) and 3 N NaOH (2×3.5 L) and water (7 L)
  8. customThe solids were transferred into a 22 L reactor
  9. additionacetone (4.7 L) was added
  10. waitThe solids were slurried for 1.5 hour
  11. washthe filtered, washing well with acetone (4.7 L)

Sources & evidence

ORD record
ord-c88b6a8af27d4d95baa86fa5e6d3c7d2
Source dataset
uspto-grants-2016_05
Patent number
US09346827B2

Reaction notes

Loading…