Cyanuric chloride → 4,6-Dichloro-1,3,5-trazin-2-amine

Temperature

25 °C

2,4,6-Trichloro-1,3,5-triazine (XVIII) (10.0 g, 55 mmol) was dissolved in acetone (80 mL) and poured into ice-water (80 mL) to form a very fine suspension. To this mixture, 1 N ammonium hydroxide solution (108 mL, 109.4 mmol) was added at 0° C. The reaction was stirred for 30 min at ambient temperature and for additional 60 min at 25° C. The precipitate was filtered off, washed with water (3×25 mL). After drying over calcium chloride under high vacuum, 6-amino-2,4-dichloro-[1,3,5]triazine (XXXVII) was isolated as white powder (7.4 g, 82% yield). LCMS (ESI) m/z=165 (M+H)+.

1. customto form a very fine suspension
2. filtrationThe precipitate was filtered off
3. washwashed with water (3×25 mL)
4. dry with materialAfter drying over calcium chloride under high vacuum

ORD record

ord-dd9cbe7642d04cfa8279d175aa5fc1ca

Source dataset

uspto-grants-2016_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09351972B2