Hydrochloric Acid → Ethyl 1-[4-(2-carboxyphenyl)phenyl]methyl-2-ethoxymethyl-4-(1-hydroxy-1-methylethyl)imidazole-5-carboxylate

HRID 53006Notes

Reaction equation

C([O:5][C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[C:14]1[CH:19]=[CH:18][C:17]([CH2:20][N:21]2[C:25]([C:26]([O:28][CH2:29][CH3:30])=[O:27])=[C:24]([C:31]([OH:34])([CH3:33])[CH3:32])[N:23]=[C:22]2[CH2:35][O:36][CH2:37][CH3:38])=[CH:16][CH:15]=1)=[O:7])(C)(C)C.Cl>>[C:6]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[C:14]1[CH:19]=[CH:18][C:17]([CH2:20][N:21]2[C:25]([C:26]([O:28][CH2:29][CH3:30])=[O:27])=[C:24]([C:31]([OH:34])([CH3:32])[CH3:33])[N:23]=[C:22]2[CH2:35][O:36][CH2:37][CH3:38])=[CH:16][CH:15]=1)([OH:7])=[O:5]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 19036121Ethyl 1-{4-[2-(t-butoxycarbonyl)phenyl]phenyl}methyl-2-ethoxymethyl-4-(1-hydroxy-1-methylethyl)imidazole-5-carboxylate

Product 1

HCID 19036064Ethyl 1-[4-(2-carboxyphenyl)phenyl]methyl-2-ethoxymethyl-4-(1-hydroxy-1-methylethyl)imidazole-5-carboxylate

Procedure

Following a procedure similar to that described in Example 96(b), but using 600 mg of ethyl 1-{4-[2-(t-butoxycarbonyl)phenyl]phenyl}methyl-2-ethoxymethyl-4-(1-hydroxy-1-methylethyl)imidazole-5-carboxylate [prepared as described in step (a) above], 585 mg of the hydrochloride of the title compound were obtained as a foam-like solid.

Sources & evidence

ORD record: ord-e1d478edef0642a6b30dfa34bc60d29d
Source dataset: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05616599

Reaction notes

Loading…