Trityl chloride → 2-Propyl-1-tritylimidazole-4,5-dicarbonitrile
Reaction equation
[CH2:1]([C:5]1[N:6]([C:14]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:7]([C:12]#[N:13])=[C:8]([C:10]#[N:11])[N:9]=1)[CH2:2][CH2:3]C.C(C1NC(C#N)=C(C#N)N=1)CC.[H-].[Na+].C(Cl)(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>>[CH2:1]([C:5]1[N:6]([C:14]([C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)([C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:7]([C:12]#[N:13])=[C:8]([C:10]#[N:11])[N:9]=1)[CH2:2][CH3:3]Participants
5
Procedure
Following a procedure similar to that described in Preparation 5(i), but using 7.8 g of 2-propylimidazole-4,5-dicarbonitrile (prepared as described in Preparation 10), 2.14 g of sodium hydride (as a 55% w/w dispersion in mineral oil) and 17.1 g of trityl chloride, 14.6 g of the title compound were obtained as crystals, melting at 107° C. (with decomposition and with a yellow coloration at 102° C.).
Sources & evidence
- ORD record
- ord-754f17e4102448f3bbc623d1ac2a006b
- Source dataset
- uspto-grants-1997_04
- Patent number
- US05616599
Reaction notes
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