反应详情

To a solution of 4-bromo-2-chloro-phenylamine (32 g, 0.15 mol) and pyridine (13.45 g, 0.17 mol) in DCM (200 mL) was added 3-chloropropionyl chloride (21.65 g, 0.17 mol) dropwise at 15° C. After stirring at room temperature for 1 hr, the mixture was washed with water and then 2 N aq. hydrochloric acid. The organic layer was dried over anhy. Na2SO4, filtered, and concentrated in vacuo to afford the title compound (10.9 g, 90% yield) as a white solid.

1. washthe mixture was washed with water
2. customThe organic layer was dried over anhy
3. filtrationNa2SO4, filtered
4. concentrationconcentrated in vacuo