Trifluoroacetic acid → HCID 118276734, compound

HRID 530622Notes

Reaction equation

HRID 530622 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][O:11][CH:10]([C:14]2[CH:19]=[CH:18][N:17]=[C:16]([CH:20]([CH3:22])[CH3:21])[N:15]=2)[CH2:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>ClCCl>[CH:20]([C:16]1[N:15]=[C:14]([CH:10]2[O:11][CH2:12][CH2:13][NH:8][CH2:9]2)[CH:19]=[CH:18][N:17]=1)([CH3:22])[CH3:21]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 117871161HCID 117871161, compound

Product 1

HCID 118276734HCID 118276734, compoundYield 101.4%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2-(2-Isopropylpyrimidin-4-yl)-morpholine-4-carboxylic acid tert-butyl ester (256 mg, 833 μmol) was dissolved in 5 mL of dichloromethane and TFA (2 mL) was added. The solution was stirred at room temperature for 2 h. The solvents were evaporated. The residue was extracted with dichloromethane and 1N NaOH solution. The organic layer was dried over Na2SO4 and concentrated. The residue was dried under vacuum to afford 2-(2-isopropylpyrimidin-4-yl)-morpholine (175 mg) as a colorless oil. (M+H)+=208 m/e.

Workup

  1. customThe solvents were evaporated
  2. extractionThe residue was extracted with dichloromethane and 1N NaOH solution
  3. dry with materialThe organic layer was dried over Na2SO4
  4. concentrationconcentrated
  5. customThe residue was dried under vacuum

Sources & evidence

ORD record
ord-a793541984bb47b38c6d65d6169c5543
Source dataset
uspto-grants-2016_05
Patent number
US09353096B2

Reaction notes

Loading…