反应详情

2.8 g (9.0 mmol) of tert-butyl 3-cyclopropylmethoxy-3-o-tolylazetidine-1-carboxylate are placed in 40 ml of a 3M solution of hydrogen chloride in ethyl acetate and are stirred at room temperature for 1 hour 30 minutes. The reaction medium is concentrated under a stream of nitrogen and then taken up in a 50/50 heptane/ethyl acetate mixture and concentrated under vacuum. 2.2 g (96%) of 3-cyclopropylmethoxy-3-o-tolylazetidine hydrochloride are obtained in the form of a beige-coloured solid.

1. concentrationThe reaction medium is concentrated under a stream of nitrogen
2. concentrationconcentrated under vacuum