Hydrochloric Acid → (6-Methylpyridazin-3-yl)methanamine hydrochloride

HRID 530805Notes

Reaction equation

HRID 530805 reaction equation
[CH3:1][C:2]1[N:7]=[N:6][C:5]([C:8]#[N:9])=[CH:4][CH:3]=1.[ClH:10]>CO.[Pd]>[ClH:10].[CH3:1][C:2]1[N:7]=[N:6][C:5]([CH2:8][NH2:9])=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 136429416-Methylpyridazine-3-carbonitrile

Product 1

HCID 90419251(6-Methylpyridazin-3-yl)methanamine hydrochloride

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of compound 2 (250 mg, 2.38 mmol) in MeOH (20 mL) was added 6N HCl (5 mL) followed by Pd/C (100 mg). The reaction mixture was kept on Parr shaker for 2 h at 40 psi. The reaction mixture was filtered through celite and washed with 5 mL of MeOH and the filtrate was concentrated to give compound 3 as a dark brown solid.

Workup

  1. filtrationThe reaction mixture was filtered through celite
  2. washwashed with 5 mL of MeOH
  3. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-cf8b83c62f094e8cb8d32193204aa5e5
Source dataset
uspto-grants-2016_05
Patent number
US09353104B2

Reaction notes

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