HRID530842

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID12052

Silane, triethyl-

C6H16Si

结构：Cc1cc(-c2nn(C(c3ccccc3)(c3ccccc3)c3ccccc3)c3ccc(C(=O)NC4CCCC(O)(Cc5ccccc5F)C4)cc23)ccn1

HCID67985157

未命名化合物

PRODUCTS

生成物

结构：Cc1cc(C2=C3CC(C(=O)NC4CCCC(O)(Cc5ccccc5F)C4)=CC=C3N=N2)ccn1

HCID86698238

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6422

未命名化合物

PROCEDURE

实验过程

N-(3-(2-fluorobenzyl)-3-hydroxycyclohexyl)-3-(2-methylpyridin-4-yl)-1-trityl-1H-indazole-5-carboxamide was stirred in neat TFA at room temperature for 10 minutes, and then Et3SiH (5 equiv.) was added. The reaction mixture was stirred at room temperature for 5 minutes, and then concentrated. The titled compound was obtained and purified by reverse phase HPLC.

WORKUP

后处理

concentrationconcentrated

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f26049ae674348768d9180de67905009
来源数据集: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09351965B2
来源说明: uspto-grants-2016_05

反应 SMILES

[F:1][C:2]1[CH:53]=[CH:52][CH:51]=[CH:50][C:3]=1[CH2:4][C:5]1([OH:49])[CH2:10][CH2:9][CH2:8][CH:7]([NH:11][C:12]([C:14]2[CH:15]=[C:16]3[C:20](=[CH:21][CH:22]=2)[N:19](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[N:18]=[C:17]3[C:42]2[CH:47]=[CH:46][N:45]=[C:44]([CH3:48])[CH:43]=2)=[O:13])[CH2:6]1.[SiH](CC)(CC)CC>C(O)(C(F)(F)F)=O>[F:1][C:2]1[CH:53]=[CH:52][CH:51]=[CH:50][C:3]=1[CH2:4][C:5]1([OH:49])[CH2:10][CH2:9][CH2:8][CH:7]([NH:11][C:12]([C:14]2[CH2:15][C:16]3[C:20](=[CH:21][CH:22]=2)[N:19]=[N:18][C:17]=3[C:42]2[CH:47]=[CH:46][N:45]=[C:44]([CH3:48])[CH:43]=2)=[O:13])[CH2:6]1