反应详情

N-(1,1-Dimethylethoxycarbonyl)glycine (6.12 g, 35 mmol) was stirred with 2,4,5-trichlorophenol (6.91 g, 35 mmol) and dicyclohexylcarbodiimide (7.22 g, 35 mmol) in ethyl acetate (100 mL) at 0° C. for 4 h. The suspension was filtered and the solvent was evaporated under reduced pressure from the filtrate. The residue was dissolved in ethyl acetate. The suspension was filtered and the solvent was evaporated under reduced pressure from the filtrate to give N-(1,1-dimethylethoxycarbonyl)glycine 2,4,5-trichlorophenyl ester (12.4 g, quantitative).

1. filtrationThe suspension was filtered
2. customthe solvent was evaporated under reduced pressure from the filtrate
3. dissolutionThe residue was dissolved in ethyl acetate
4. filtrationThe suspension was filtered
5. customthe solvent was evaporated under reduced pressure from the filtrate