Diisopropylethylamine → HCID 67983110, compound
Reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:17](O)=[O:18])[CH:15]=3)[N:10]([C:20]([C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[N:9]=2)[CH:5]=[CH:4][N:3]=1.[NH2:39][N:40]1[CH2:45][CH2:44][CH2:43][C:42]([CH2:55][OH:56])([O:46][C:47]2[CH:52]=[C:51]([F:53])[CH:50]=[CH:49][C:48]=2[F:54])[CH2:41]1.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.CCN(C(C)C)C(C)C>CC(N(C)C)=O>[F:54][C:48]1[CH:49]=[CH:50][C:51]([F:53])=[CH:52][C:47]=1[O:46][C:42]1([CH2:55][OH:56])[CH2:43][CH2:44][CH2:45][N:40]([NH:39][C:17]([C:14]2[CH:15]=[C:16]3[C:11](=[CH:12][CH:13]=2)[N:10]([C:20]([C:33]2[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=2)([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)[N:9]=[C:8]3[C:6]2[CH:5]=[CH:4][N:3]=[C:2]([CH3:1])[CH:7]=2)=[O:18])[CH2:41]1Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
A reaction mixture of 3-(2-methylpyridin-4-yl)-1-trityl-1H-indazole-5-carboxylic acid (0.3 mmol, 150 mg), (1-amino-3-(2,5-difluorophenoxy)piperidin-3-yl)methanol (0.28 mmol, 81 mg), HATU (0.3 mmol, 115 mg) and DIEA in DMA was stirred at room temperature for overnight. The product, N-(3-(2,5-difluorophenoxy)-3-(hydroxymethyl)piperidin-1-yl)-3-(2-methylpyridin-4-yl)-1-trityl-1H-indazole-5-carboxamide, was obtained after rotary evaporation of solvent.
Sources & evidence
- ORD record
- ord-30b23e4398184524ab27d58d5789a3a4
- Source dataset
- uspto-grants-2016_05
- Patent number
- US09351965B2
Reaction notes
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