反应详情

Dibromoisocyanuric acid (10.6 g) was added at 15° C. to 30° C. to a DMF (90 mL) solution of 4′-fluoro-3-methoxybiphenyl-4-carbaldehyde (16.0 g), and the mixture was stirred for 40 minutes. Then, water (30 mL) was added thereto, and the mixture was further stirred for 1 hour. The deposited solid was collected by filtration and washed with a mixed solution of DMF (15 mL) and water (15 mL) and water (30 mL) in this order to obtain the title compound (20.6 g).

1. stirringthe mixture was further stirred for 1 hour
2. filtrationThe deposited solid was collected by filtration
3. washwashed with a mixed solution of DMF (15 mL) and water (15 mL) and water (30 mL) in this order