反应详情

Dibromoisocyanuric acid (3.39 g) was added to a solution of 3-ethoxy-2′,4′-difluorobiphenyl-4-carbaldehyde (5.16 g) in DMF (30 mL) at room temperature. The mixture was stirred at room temperature for 4 hours. Water (6 mL) was added to the mixture. Then the crystalline seed was added to the mixture. The mixture was stirred at room temperature for 1 hour. The precipitate was collected by filtration, washed with DMF-water (8 mL-2 mL), and dried at 70° C. to give the title compound (6.00 g).

1. additionThen the crystalline seed was added to the mixture
2. stirringThe mixture was stirred at room temperature for 1 hour
3. filtrationThe precipitate was collected by filtration
4. washwashed with DMF-water (8 mL-2 mL)
5. customdried at 70° C.