1,1'-Carbonyldiimidazole → HCID 72189374, compound

HRID 531292Notes

Reaction equation

HRID 531292 reaction equation
[F:1][C:2]([F:52])([F:51])[C:3]1[CH:4]=[C:5]([C@H:13]2[O:17][C:16](=[O:18])[N:15]([CH2:19][C:20]3[C:25]([C:26]4[CH:27]=[C:28]([C:34]5[CH:43]=[CH:42][C:37]([C:38]([NH:40][NH2:41])=[O:39])=[CH:36][C:35]=5[CH3:44])[CH:29]=[N:30][C:31]=4[O:32][CH3:33])=[CH:24][N:23]=[C:22]([N:45]4[CH2:48][CH:47]([F:49])[CH2:46]4)[N:21]=3)[C@H:14]2[CH3:50])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.C1N=CN([C:58](N2C=NC=C2)=[O:59])C=1>C1COCC1>[F:10][C:9]([F:12])([F:11])[C:7]1[CH:6]=[C:5]([C@H:13]2[O:17][C:16](=[O:18])[N:15]([CH2:19][C:20]3[C:25]([C:26]4[CH:27]=[C:28]([C:34]5[CH:43]=[CH:42][C:37]([C:38]6[O:39][C:58](=[O:59])[NH:41][N:40]=6)=[CH:36][C:35]=5[CH3:44])[CH:29]=[N:30][C:31]=4[O:32][CH3:33])=[CH:24][N:23]=[C:22]([N:45]4[CH2:48][CH:47]([F:49])[CH2:46]4)[N:21]=3)[C@H:14]2[CH3:50])[CH:4]=[C:3]([C:2]([F:1])([F:51])[F:52])[CH:8]=1

Participants

4

Reactant 2

HCID 682631,1'-CarbonyldiimidazoleHCID 90009162HCID 90009162, compound

Product 1

HCID 72189374HCID 72189374, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 4-{5-[4-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-2-(3-fluoroazetidin-1-yl)pyrimidin-5-yl]-6-methoxypyridin-3-yl}-3-methylbenzohydrazide (Step A, 108 mg, 0.147 mmol) in THF (1.5 mL) was treated with N,N-carbonyldiimidazole (71.6 mg, 0.442 mmol). The reaction was stirred at room temperature overnight. The reaction was purified directly by silica gel chromatography, eluting with a gradient of 25-100% ethyl acetate/hexanes to give the titled compound. LCMS (M+H)+: 760.5. 1H NMR (CDCl3, 500 MHz): δ 9.08 (br, 1H), 8.22 (d, 1H), 8.18 (s, 1H), 7.89 (s, 1H), 7.78 (s, 1H), 7.74 (s, s, 3H), 7.49 (d, 1H), 7.36 (d, 1H), 5.68 (d, 1H), 5.51 (m, 0.5H), 5.40 (m, 0.5H), 4.73 (d, 1H), 4.47 (m, 3H), 4.31 (m, 2H), 4.01 (m, s, 4H), 2.38 (s, 3H), 0.76 (d, 3H). RTA IC50: 12 nM.

Workup

  1. customThe reaction was purified directly by silica gel chromatography
  2. washeluting with a gradient of 25-100% ethyl acetate/hexanes

Sources & evidence

ORD record
ord-70e8ac3c584e49f08d0b0ad0bff596bd
Source dataset
uspto-grants-2016_05
Patent number
US09353101B2

Reaction notes

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