反应详情

To a 125 mL round-bottomed flask equipped with condenser and nitrogen inlet were added 5.20 grams (21.49 mmol) 4-cyclohexyl 7-methyl-1,2,3,4-tetrahydronaphth-1-one, 54 mL methanol, 3.25 grams (32.23 mmol) triethylamine, and 2.22 grams (32.23 mmol) hydroxylamine hydrochloride. The reaction was stirred at room temperature for 1.5 days, evaporated, partitioned between ethyl acetate and water, and the aqueous layer extracted with fresh ethyl acetate. The combined organic layer was dried over sodium sulfate and evaporated to an oil, which was used directly.

1. customTo a 125 mL round-bottomed flask equipped with condenser and nitrogen inlet
2. customevaporated
3. custompartitioned between ethyl acetate and water
4. extractionthe aqueous layer extracted with fresh ethyl acetate
5. dry with materialThe combined organic layer was dried over sodium sulfate
6. customevaporated to an oil, which