反应详情

To a solution of 3-(1-(3-fluorobenzyl)-1H-pyrazol-4-yl)-5-(4-(piperazin-1-yl)phenyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine (75 mg, 0.123 mmol) and 2-cyclopropylacetic acid hydrochloride (26 mg, 0.185 mmol) in DMF (2 mL) was added HATU (71 mg, 0.185 mmol), HOBt (25 mg, 0.185 mmol) and DIPEA (86 μL, 0.494 mmol) and stirred at RT overnight. Added ice water and extracted with 10% methanol in DCM. Organic layer was washed with brine solution, dried over sodium sulphate and distilled out the solvent to get 60 mg (70.58%) yield of the title compound. MS: m/z=689.2 (M+1).

1. extractionAdded ice water and extracted with 10% methanol in DCM
2. washOrganic layer was washed with brine solution
3. dry with materialdried over sodium sulphate
4. distillationdistilled out the solvent