反应详情

Ethyl 3-Hydroxybutyrate (6.5 ml) was dissolved in THF (350.0 ml) at 0° C. and NaH (4.8 g) was added. The reaction was stirred at room temperature for 30 min. Then 5.5 g 2,4-difluoronitrobenzene was added and the mixture was heated at reflux overnight. The reaction was concentrated in vacuo and the residue was dissolved in water and dichloromethane. The organic layer was separated, dried and concentrated in vacuo. The residue was purified by chromatography (silica/dichloromethane) to yield the title compound.

1. temperaturethe mixture was heated
2. temperatureat reflux overnight
3. concentrationThe reaction was concentrated in vacuo
4. dissolutionthe residue was dissolved in water
5. customThe organic layer was separated
6. customdried
7. concentrationconcentrated in vacuo
8. customThe residue was purified by chromatography (silica/dichloromethane)