HCID 58413322, compound → HCID 58413335, compound

HRID 532261Notes

Reaction equation

HRID 532261 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([N+:17]([O-])=O)=[C:6]([CH:16]=1)[O:7][CH:8]([CH3:15])[CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11]>C1COCC1.[Ni]>[CH2:13]([O:12][C:10](=[O:11])[CH2:9][CH:8]([O:7][C:6]1[CH:16]=[C:2]([F:1])[CH:3]=[CH:4][C:5]=1[NH2:17])[CH3:15])[CH3:14]

Participants

4

Reactant 1

HCID 58413322HCID 58413322, compound

Product 1

HCID 58413335HCID 58413335, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of Ethyl 3-(5-fluoro-2-nitrophenoxy)butanoate (1.3 g) in THF (50 ml) was added Raney nickel (150 mg) and the reaction mixture was hydrogenated. The catalyst was filtered off and the filtrate was concentrated in vacuo.

Workup

  1. filtrationThe catalyst was filtered off
  2. concentrationthe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-a28b34769c7d485f8ff2a6a776d9146c
Source dataset
uspto-grants-2014_10
Patent number
US08853193B2

Reaction notes

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