Hexylene Glycol → HCID 58413282, compound

HRID 532263Notes

Reaction equation

HRID 532263 reaction equation
[CH3:1][C:2]([OH:8])([CH2:4][CH:5]([OH:7])[CH3:6])[CH3:3].[H-].[Na+].F[C:12]1[CH:17]=[C:16]([F:18])[CH:15]=[CH:14][C:13]=1[N+:19]([O-:21])=[O:20]>C1COCC1>[F:18][C:16]1[CH:15]=[CH:14][C:13]([N+:19]([O-:21])=[O:20])=[C:12]([CH:17]=1)[O:7][CH:5]([CH3:6])[CH2:4][C:2]([CH3:3])([OH:8])[CH3:1]

Participants

5

Reactant 3

HCID 7870Hexylene GlycolHCID 24758Sodium hydrideHCID 679672,4-Difluoronitrobenzene

Product 1

HCID 58413282HCID 58413282, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2-Methylpentane-2,4-diol (2.8 ml) was dissolved in THF (20.0 ml) and NaH (60% in mineral oil; 1 g) was added. At room temperature 2,4-difluoronitrobenzene was added and the reaction mixture was stirred overnight. Then the reaction was quenched with water and concentrated in vacuo. The residue was dissolved in dichloromethane, washed with water and concentrated in vacuo.

Workup

  1. customThen the reaction was quenched with water
  2. concentrationconcentrated in vacuo
  3. dissolutionThe residue was dissolved in dichloromethane
  4. washwashed with water
  5. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-4acc7d17143347b380958086455ca6df
Source dataset
uspto-grants-2014_10
Patent number
US08853193B2

Reaction notes

Loading…