反应详情

温度

0 °C

1,3-Difluoro-propan-2-ol (4.2 g) was dissolved under argon in THF (250 ml) and cooled to 0° C. LiHMDS (28 ml) was added to the mixture and stirred at rt for 1 hour. Then the mixture was cooled to 0° C. and 3-fluoro-4-nitrobenzonitrile (1.95 ml) was added in portions and stirred for 2 hours. The mixture was poured in water and extracted with DCM. The organic layer was washed with water, dried and concentrated.

1. temperatureThen the mixture was cooled to 0° C.
2. stirringstirred for 2 hours
3. extractionextracted with DCM
4. washThe organic layer was washed with water
5. customdried
6. concentrationconcentrated