2-Aminothiazole → 2-Amino-3-methylthiazolium p-toluenesulfonate

HRID 53230Notes

Reaction equation

HRID 53230 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[CH:5][N:6]=1.[C:7]1([CH3:18])[CH:12]=[CH:11][C:10]([S:13]([O:16]C)(=[O:15])=[O:14])=[CH:9][CH:8]=1>CC(C)=O>[C:7]1([CH3:18])[CH:8]=[CH:9][C:10]([S:13]([O-:16])(=[O:14])=[O:15])=[CH:11][CH:12]=1.[NH2:1][C:2]1[S:3][CH:4]=[CH:5][N+:6]=1[CH3:7]

Participants

4

Reactant 2

HCID 21552-AminothiazoleHCID 6645Methyl p-toluenesulfonate

Product 1

HCID 199621872-Amino-3-methylthiazolium p-toluenesulfonate

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Conditions

Temperature
60 °C

Procedure

In a 200 ml three-necked flask were placed 2.0 g of 2-aminothiazole and 5.6 g of methyl p-toluenesulfonate, and the mixture was stirred at 120° C. for 4 hours. After the resulting mixture was cooled to 60° C., 100 ml of acetone was added and the mixture was stirred for 1 hour. The precipitates were filtered under reduced pressure, washed with acetone, and dried at room temperature under reduced pressure.

Workup

  1. customIn a 200 ml three-necked flask were placed
  2. filtrationThe precipitates were filtered under reduced pressure
  3. washwashed with acetone
  4. customdried at room temperature under reduced pressure

Sources & evidence

ORD record
ord-395da0d658534a0ebfa6c8c8e18e359e
Source dataset
uspto-grants-1997_04
Patent number
US05618831

Reaction notes

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