Potassium Cyanide → HCID 58136957, compound

HRID 532334Notes

Reaction equation

HRID 532334 reaction equation
CS([C:5]1[C:6]([CH3:16])=[C:7]([CH3:15])[C:8]2[N:9]([C:11]([NH2:14])=[N:12][N:13]=2)[N:10]=1)(=O)=O.[C-:17]#[N:18].[K+]>CN(C=O)C>[NH2:14][C:11]1[N:9]2[N:10]=[C:5]([C:17]#[N:18])[C:6]([CH3:16])=[C:7]([CH3:15])[C:8]2=[N:13][N:12]=1

Participants

4

Reactant 2

HCID 9032Potassium CyanideHCID 58136894HCID 58136894, compound

Product 1

HCID 58136957HCID 58136957, compoundYield 71.8%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
100 °C

Procedure

6-Methanesulfonyl-7,8-dimethyl-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine (W1.130; 1.0 g) was dissolved in DMF (30 ml) and admixed with potassium cyanide (405 mg). After stirring at 100° C. for 1 h, the mixture was dried. The residue was stirred in EA and chromatographed using a short silica gel column with EA. Fractions concentrated by rotary evaporation. 560 mg of the title compound were obtained.

Workup

  1. customthe mixture was dried
  2. stirringThe residue was stirred in EA
  3. customchromatographed
  4. concentrationFractions concentrated by rotary evaporation

Sources & evidence

ORD record
ord-635a419a31ba4db2a10d73ccb56c3507
Source dataset
uspto-grants-2014_10
Patent number
US08853206B2

Reaction notes

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