反应详情

温度

0 °C

Sodium bicarbonate was dissolved in water, and a solution of 4-hydroxypiperidine in dichloromethane and BrCN were added thereto at 0° C. The reaction mixture was stirred at 0° C. for 30 min and further stirred at room temperature for 2 hours. After completion of the reaction, the reaction mixture was extracted twice with dichloromethane. The organic layer thus obtained was dried over anhydrous sodium sulfate, and concentrated under reduced pressure to obtain the title compound.

1. customat 0° C
2. stirringfurther stirred at room temperature for 2 hours
3. customAfter completion of the reaction
4. extractionthe reaction mixture was extracted twice with dichloromethane
5. customThe organic layer thus obtained
6. dry with materialwas dried over anhydrous sodium sulfate
7. concentrationconcentrated under reduced pressure