Triethylamine → HCID 43393084, compound

HRID 532480Notes

Reaction equation

HRID 532480 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([OH:7])[CH2:3][CH2:2]1.[C:8]([N:12]=[C:13]=[O:14])([CH3:11])([CH3:10])[CH3:9].C(N(CC)CC)C>ClCCl>[C:8]([NH:12][C:13]([N:1]1[CH2:6][CH2:5][CH:4]([OH:7])[CH2:3][CH2:2]1)=[O:14])([CH3:11])([CH3:10])[CH3:9]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 62412tert-Butyl isocyanateHCID 79341Piperidin-4-ol

Product 1

HCID 43393084HCID 43393084, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Piperidin-4-ol (1 g) was dissolved in dichloromethane, and tert-butyl isocyanate was added thereto. Then, triethylamine was added thereto at room temperature, and the reaction mixture was stirred for 2 hours. After completion of the reaction, the reaction mixture was concentrated under reduced pressure to remove the solvent, crystallized in the presence of ether 50 mL, and filtered to obtain the title compound (1.8 g) as a white solid.

Workup

  1. customAfter completion of the reaction
  2. concentrationthe reaction mixture was concentrated under reduced pressure
  3. customto remove the solvent
  4. customcrystallized in the presence of ether 50 mL
  5. filtrationfiltered

Sources & evidence

ORD record
ord-cb359c240ae64bcb8630f130f59cf6d0
Source dataset
uspto-grants-2014_10
Patent number
US08853213B2

Reaction notes

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