反应详情

温度

0 °C

30 mg of 1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-ol was dissolved in 2 ml of N,N-dimethylformamide and cooled to 0° C. 9 mg of NaH was added to the mixture and stirred for 30 min. 50 mg of 7-bromo-4-chloro-thieno[3,2-d]pyrimidine was added to the mixture, heated to room temperature and stirred for 2 hr. The resulting mixture was added with aqueous ammonium chloride and extracted twice with ethyl acetate. The organic layer was washed with water, dried over anhydrous sodium sulfate, and concentrated under a reduced pressure to obtain a bubble residue. The resulting residue was crystallized in diethylether solvent to obtain 50 mg of the title compound as a white solid.

1. temperatureheated to room temperature
2. stirringstirred for 2 hr
3. extractionextracted twice with ethyl acetate
4. washThe organic layer was washed with water
5. dry with materialdried over anhydrous sodium sulfate
6. concentrationconcentrated under a reduced pressure
7. customto obtain a bubble residue
8. customThe resulting residue was crystallized in diethylether solvent