反应详情

温度

-10 °C

A solution of 5.74 g isobutylchloroformiate (42 mmol) in 50 ml THF was slowly added drop by drop in 30 minutes to a mixture containing 4.57 g traumatic acid (20 mmol) and 4.26 g triethylamine (42 mmol) in 150 ml anhydrous THF under stirring at -10° C. The mixture was maintained under stirring at -10° C. for 2 hours and subsequently at 0° C. for 15 hours. 3.5 g ethanolamine were slowly added drop by drop in 30 minutes.

1. customin 30 minutes
2. temperatureThe mixture was maintained
3. stirringunder stirring at -10° C. for 2 hours and subsequently at 0° C. for 15 hours
4. customin 30 minutes