Trifluoroacetic acid → HCID 178511732, compound

HRID 532531Notes

Reaction equation

HRID 532531 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[CH:9]1[C@@H:14]([NH:15]C(=O)OC(C)(C)C)[CH2:13][C@@H:12]([N:23]2[CH2:30][C:29]3[C:25](=[N:26][NH:27][CH:28]=3)[CH2:24]2)[CH2:11][S:10]1.[C:31]([OH:37])([C:33]([F:36])([F:35])[F:34])=[O:32]>C(Cl)Cl>[F:34][C:33]([F:36])([F:35])[C:31]([OH:37])=[O:32].[F:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[CH:9]1[C@@H:14]([NH2:15])[CH2:13][C@@H:12]([N:23]2[CH2:30][C:29]3[C:25](=[N:26][NH:27][CH:28]=3)[CH2:24]2)[CH2:11][S:10]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178454095HCID 178454095, compound

Product 1

HCID 178511732HCID 178511732, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-Butyl N-[(3S,5R)-2-(2,5-difluorophenyl)-5-(4,6-dihydro-2H-pyrrolo[3,4-c]pyrazol-5-yl)tetrahydrothiopyran-3-yl]carbamate (3.2 mg, 0.007 mmol) was dissolved in a mixture of TFA (0.5 mL) and methylene chloride (1.0 mL) and stirred at RT for 1 h. The solvents were evaporated and the residue was freeze-dried from a mixture of benzene and ethanol to give the title compound as a white solid.

Workup

  1. customThe solvents were evaporated
  2. dry with materialthe residue was freeze-dried from a mixture of benzene and ethanol

Sources & evidence

ORD record
ord-03b559a8dc824ea8a79932c96409a205
Source dataset
uspto-grants-2014_10
Patent number
US08853212B2

Reaction notes

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