Trifluoroacetic acid → HCID 178511733, compound

HRID 532532Notes

Reaction equation

HRID 532532 reaction equation
[N:1]1[NH:2][CH:3]=[C:4]2[CH2:8][N:7]([C@H:9]3[CH2:14][S:13](=[O:15])[CH:12]([C:16]4[CH:21]=[C:20]([F:22])[CH:19]=[C:18]([F:23])[C:17]=4[F:24])[C@@H:11]([NH:25]C(=O)OC(C)(C)C)[CH2:10]3)[CH2:6][C:5]=12.[C:33]([OH:39])([C:35]([F:38])([F:37])[F:36])=[O:34]>C(Cl)Cl>[F:36][C:35]([F:38])([F:37])[C:33]([OH:39])=[O:34].[N:1]1[NH:2][CH:3]=[C:4]2[CH2:8][N:7]([C@H:9]3[CH2:14][S:13](=[O:15])[CH:12]([C:16]4[CH:21]=[C:20]([F:22])[CH:19]=[C:18]([F:23])[C:17]=4[F:24])[C@@H:11]([NH2:25])[CH2:10]3)[CH2:6][C:5]=12

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178454096HCID 178454096, compound

Product 1

HCID 178511733HCID 178511733, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-Butyl N-[(3S,5R)-5-(4,6-dihydro-2H-pyrrolo[3,4-c]pyrazol-5-yl)-1-oxo-2-(2,3,5-trifluorophenyl)thian-3-yl]carbamate was dissolved in a mixture of TFA (0.02 mL) and methylene chloride (0.2 mL). After stirring at RT for 105 min, the solvents were evaporated and the residue was freeze-dried from a mixture of benzene and ethanol to give the title compound as a white solid.

Workup

  1. customthe solvents were evaporated
  2. dry with materialthe residue was freeze-dried from a mixture of benzene and ethanol

Sources & evidence

ORD record
ord-5d28f72bba65432194f70ad86be09161
Source dataset
uspto-grants-2014_10
Patent number
US08853212B2

Reaction notes

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