Lithium Hydroxide → HCID 59671070, compound

HRID 532720Notes

Reaction equation

HRID 532720 reaction equation
C([O:4][C@H:5]1[C:9]2[N:10]=[CH:11][N:12]=[C:13]([N:14]3[CH2:19][CH2:18][N:17]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:16][C@@H:15]3[CH3:27])[C:8]=2[C@H:7]([CH3:28])[CH2:6]1)(=O)C.[Li+].[OH-]>C1COCC1>[OH:4][C@H:5]1[C:9]2[N:10]=[CH:11][N:12]=[C:13]([N:14]3[CH2:19][CH2:18][N:17]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:16][C@@H:15]3[CH3:27])[C:8]=2[C@H:7]([CH3:28])[CH2:6]1

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 66617875HCID 66617875, compound

Product 1

HCID 59671070HCID 59671070, compoundYield 82.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of the (S)-tert-butyl 4-((5R,7R)-7-acetoxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-3-methylpiperazine-1-carboxylate (0.281 g, 0.72 mmol) in THF (5 mL) was added LiOH (3M, 2 mL). The mixture was stirred at room temperature for 6 hours and then quenched with 2N HCl (3 mL). The solvent was removed and the residue was purified by silica gel chromatography, eluting with ethyl acetate to give (S)-tert-butyl 4-((5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)-3-methylpiperazine-1-carboxylate (0.206 g, 82%). 1H NMR (CDCl3, 400 MHz) δ 8.52 (s, 1H), 5.12 (m, 1H), 4.76 (br, 1H), 4.30-3.80 (m, 3H), 3.52 (m, 1H), 3.26 (m, 1H), 3.03 (br, 1H), 2.20 (m, 1H), 1.49 (s, 9H), 1.30-1.10 (m, 6H). MS (APCI+) [M+H] +349.

Workup

  1. customquenched with 2N HCl (3 mL)
  2. customThe solvent was removed
  3. customthe residue was purified by silica gel chromatography
  4. washeluting with ethyl acetate

Sources & evidence

ORD record
ord-fdbaa3a17c3f4c06beb51c00416c17a1
Source dataset
uspto-grants-2014_10
Patent number
US08853199B2

Reaction notes

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