Ammonia → HCID 178497268, compound

HRID 533419Notes

Reaction equation

HRID 533419 reaction equation
[CH3:1][C:2]1[O:3][C:4](=O)[C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[C:7]([C:12]([O:14][CH3:15])=[O:13])[CH:6]=2.[NH3:17].Cl>C1COCC1>[OH:3][C:4]1[C:5]2[C:10](=[CH:9][CH:8]=[C:7]([C:12]([O:14][CH3:15])=[O:13])[CH:6]=2)[CH:11]=[C:2]([CH3:1])[N:17]=1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 67776040HCID 67776040, compound

Product 1

HCID 178497268HCID 178497268, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of methyl 3-methyl-1-oxo-1H-isochromene-7-carboxylate (1.0 g), 29% aqueous ammonia solution (30 mL) and THF (30 mL) was stirred at room temperature for 8 hours. The reaction mixture was neutralized with hydrochloric acid, and the precipitate was collected by filtration to obtain methyl 1-hydroxy-3-methylisoquinoline-7-carboxylate (390 mg).

Workup

  1. filtrationthe precipitate was collected by filtration

Sources & evidence

ORD record
ord-edcbcc2b6f774606aee5d3a8a19a0f3d
Source dataset
uspto-grants-2014_10
Patent number
US08853242B2

Reaction notes

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