Oxalic acid dihydrate → HCID 86731815, compound

HRID 533684Notes

Reaction equation

HRID 533684 reaction equation
[CH:1]1[CH:2]=[CH:3][C:4]2[S:9][N:8]=[C:7]([N:10]3[CH2:15][CH2:14][N:13]([CH2:16][C@H:17]4[C@H:22]([CH2:23][N:24]5[C:34](=[O:35])[C@H:33]6[C@H:27]([C@H:28]7[CH2:32][C@@H:31]6[CH2:30][CH2:29]7)[C:25]5=[O:26])[CH2:21][CH2:20][CH2:19][CH2:18]4)[CH2:12][CH2:11]3)[C:5]=2[CH:6]=1.O.O.[C:38]([OH:43])(=[O:42])[C:39]([OH:41])=[O:40]>CC(C)=O>[CH:1]1[CH:2]=[CH:3][C:4]2[S:9][N:8]=[C:7]([N:10]3[CH2:15][CH2:14][N:13]([CH2:16][C@H:17]4[C@H:22]([CH2:23][N:24]5[C:34](=[O:35])[C@H:33]6[C@H:27]([C@H:28]7[CH2:32][C@@H:31]6[CH2:30][CH2:29]7)[C:25]5=[O:26])[CH2:21][CH2:20][CH2:19][CH2:18]4)[CH2:12][CH2:11]3)[C:5]=2[CH:6]=1.[C:38]([O-:43])(=[O:42])[C:39]([O-:41])=[O:40]

Participants

4

Reactant 2

HCID 61373Oxalic acid dihydrateHCID 213046Lurasidone

Product 1

HCID 86731815HCID 86731815, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture consisting of acetone (4750 mL) and lurasidone base (431 g) is refluxed until dissolved. Oxalic acid dihydrate (110 g) is added, and the mixture is cooled to ambient temperature, and then cooled for two hours at 10° C. The solid is filtered, and 435 g of substantially pure lurasidone oxalate is obtained after drying.

Workup

  1. temperatureis refluxed
  2. dissolutionuntil dissolved
  3. temperaturecooled for two hours at 10° C
  4. filtrationThe solid is filtered

Sources & evidence

ORD record
ord-71523231d30a41849b6f74a7502f2d28
Source dataset
uspto-grants-2014_10
Patent number
US08853395B2

Reaction notes

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